CJC-1295 + GHRP-2: The Stronger, Less Selective GH Blend
Also known as: CJC-1295 + GHRP-2 · CJC/GHRP-2
Structurally this is the same idea as the ipamorelin blend — a GHRH analog paired with a GHRP so one pushes GH release while the other suppresses somatostatin — but with GHRP-2 in place of ipamorelin. GHRP-2 is the older and more potent of the two, and it is less selective: alongside GH it produces meaningful increases in prolactin and cortisol, which ipamorelin largely avoids. It also stimulates appetite noticeably. Whether that trade is worth it depends entirely on what you are trying to do. Educational only, not medical advice.
GHRP-2 versus ipamorelin
Both are ghrelin-receptor agonists and both suppress somatostatin, so both do the "release the brake" half of the pairing. The difference is what else they do.
GHRP-2 is more potent at raising GH but also raises prolactin and cortisol, and stimulates appetite strongly through the same ghrelin pathway. Ipamorelin was developed specifically to be selective — comparable GH release with minimal effect on those other hormones. That selectivity is why ipamorelin displaced GHRP-2 as the default in modern blends.
Appetite is the underrated variable. If your goal involves a calorie deficit, a compound that markedly increases hunger is working against the thing that actually determines fat loss.
Ratio and dosing pattern
Sold as a single lyophilized vial, typically 1:1 by weight, reconstituted together. Both components here have short half-lives — roughly 30 minutes each — so the schedules at least match, which is a genuine advantage over the DAC blend.
Because both clear quickly, this blend is usually dosed on an empty stomach, most often before bed to align with the body's largest natural GH pulse. Food, particularly carbohydrate and fat, blunts the GH response, which is why timing away from meals is the standard advice.
What to watch
If you are running a GHRP that raises prolactin, prolactin is a reasonable lab to check rather than assume. Elevated prolactin can produce its own symptoms and is worth catching on paper rather than by feel.
IGF-1 tracks the downstream GH effect, and fasting glucose is worth watching because GH opposes insulin. As with every blend on this page: the GHRH-plus-GHRP mechanism is supported, this specific product is not a studied formulation.
How to track CJC-1295 + GHRP-2 in Stackeddd
If you are running this one, prolactin is the marker that distinguishes it from the ipamorelin version — log it alongside IGF-1 so you can see whether the trade-off is showing up in your bloodwork rather than guessing from symptoms.
Model it yourself · free, no account
Reconstitution Calculator
A blend is one reconstitution that sets the dose of every compound in the vial — get the water volume right once and every draw after it is correct.
Related compounds
Related reading: What peptides can you mix in the same syringe? · Peptide reconstitution math: how much BAC water to add
Frequently asked questions
Is GHRP-2 stronger than ipamorelin?
At raising GH, generally yes. But it is also less selective — it raises prolactin and cortisol and stimulates appetite noticeably, which ipamorelin largely does not. Ipamorelin became the default in modern blends because of that selectivity rather than raw potency.
Why is this blend taken on an empty stomach?
Food, particularly carbohydrate and fat, blunts the growth-hormone response. Dosing away from meals — commonly before bed, to align with the largest natural GH pulse — is the standard approach for that reason.
Should I check prolactin on GHRP-2?
It is the marker that meaningfully separates GHRP-2 from ipamorelin, so checking it rather than assuming is reasonable if you are running this blend. Any decision about it belongs with your prescriber.
This is educational information, not medical advice. Doses and protocols above reflect published references and community practice — protocol decisions belong with your prescribing physician. Generic names used throughout. How this reference is built & how the AI is tested →
STACKEDDD
Track it instead of guessing.
Doses, reconstitution, bloodwork, and an AI coach grounded in your own data — free to start, on the App Store and Google Play.