CJC-1295 + Ipamorelin: What the Blend Is and Why They Are Paired
Also known as: CJC-1295 (No DAC) + Ipamorelin · CJC-1295 + Ipamorelin · CJC/Ipa · Mod GRF 1-29 + Ipamorelin
This is the most common GH-peptide blend sold, and it is the one pairing where the logic is genuinely supported rather than assumed. CJC-1295 without DAC is a GHRH analog — it tells the pituitary to release growth hormone. Ipamorelin is a GHRP, a ghrelin-receptor agonist that suppresses somatostatin, the body's GH "off switch." Giving a release signal while lifting the brake produces a larger GH pulse than either does alone, and that two-pathway synergy is documented in human endocrine research. What is *not* studied is this vial: the ratio, the mixing, and the long-term use of the combination as sold are not a researched protocol. Educational only, not medical advice.
Why these two are paired
Growth-hormone release is governed by two opposing signals. GHRH from the hypothalamus tells the pituitary to release GH; somatostatin tells it to stop. A GHRH analog on its own pushes the accelerator, but if somatostatin tone is high at that moment, the pituitary barely responds.
A GHRP works on a separate receptor entirely — the ghrelin receptor — and one of its effects is to suppress somatostatin. So the pairing is not two drugs doing the same job harder. It is one compound pressing the accelerator and another releasing the brake, which is why combined GHRH + GHRP administration produces a substantially larger GH pulse than the sum of either alone. This synergy is the reason essentially every GH-peptide blend on the market follows this template.
Ipamorelin specifically is chosen over older GHRPs because it is the most selective of them — it triggers GH release with comparatively little effect on cortisol and prolactin, which the earlier GHRPs raise.
Ratio, mixing and what "no DAC" changes
Blends are usually sold as a single lyophilized vial containing both peptides, most often at a 1:1 ratio by weight — a 5 mg/5 mg or 2 mg/2 mg vial. Because both are reconstituted together, you cannot dose them independently; the ratio is fixed at purchase. That is the real trade-off of buying a blend rather than two vials.
The no-DAC version matters more than people expect. CJC-1295 without DAC (also sold as Mod GRF 1-29) has a half-life of roughly 30 minutes, so it produces a short, sharp pulse that mimics natural GH release. The DAC version lasts about a week and holds GH elevated continuously — a different pharmacological strategy with a different side-effect profile. A blend labelled simply "CJC-1295 + ipamorelin" is usually the no-DAC form, but this is exactly the kind of thing worth confirming rather than assuming.
Both peptides are stable in bacteriostatic water and are routinely reconstituted in the same vial, which is what a pre-mixed blend is.
What the combination evidence actually supports
The mechanism is well supported: combined GHRH-analog and GHRP administration raises GH more than either alone in controlled human studies. That is real, and it is why the pairing exists.
What does not exist is evidence for this blend as a *product* — no trials of this ratio, this dosing schedule, or long-term use in healthy adults seeking body-composition changes. Raising GH is a measurable pharmacological effect; it is not the same as a demonstrated outcome in muscle, fat, sleep or recovery. Those are the claims blend marketing makes and the literature does not carry.
If you are tracking anything on a GH peptide, IGF-1 is the downstream marker that reflects sustained GH exposure, and fasting glucose is the one worth watching in the other direction, since GH opposes insulin.
How to track CJC-1295 (No DAC) + Ipamorelin in Stackeddd
Log the blend as one item with its total vial size, and treat the reconstitution math as the thing to get right — a 1:1 blend means every unit you draw carries both peptides, so a dose change moves both at once. Trend IGF-1 alongside it if you are drawing labs.
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Reconstitution Calculator
Reconstitute it once, correctly: enter the vial size and your BAC water and get the exact syringe units for the dose you want — with a blend, one wrong conversion misdoses both peptides.
Related compounds
Related reading: What peptides can you mix in the same syringe? · Peptide reconstitution math: how much BAC water to add
Frequently asked questions
Why combine CJC-1295 with ipamorelin instead of using one?
They act on two different receptors that control the same output. CJC-1295 signals the pituitary to release GH; ipamorelin suppresses somatostatin, the signal that stops release. Combining a release signal with brake removal produces a larger GH pulse than either compound alone, and that synergy is documented in human research.
What ratio is the CJC-1295 and ipamorelin blend sold at?
Most commonly 1:1 by weight — for example a 5 mg / 5 mg vial. Because both peptides are reconstituted together, the ratio is fixed when you buy it and you cannot adjust one without adjusting the other.
Is the blend itself backed by studies?
The mechanism is, the product is not. Combined GHRH-analog plus GHRP dosing raising GH more than either alone is established. This specific vial, ratio and schedule has not been studied, and raising GH is not by itself evidence of a body-composition or recovery outcome.
Does it matter whether the CJC-1295 has DAC?
Considerably. Without DAC the half-life is around 30 minutes, producing a short pulse close to natural GH release. With DAC it is roughly a week, holding GH elevated continuously. They are different strategies, and a blend labelled only "CJC-1295" does not tell you which one is in the vial.
This is educational information, not medical advice. Doses and protocols above reflect published references and community practice — protocol decisions belong with your prescribing physician. Generic names used throughout. How this reference is built & how the AI is tested →
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