What Is SLU-PP-332? Dosage, Half-Life & How to Track It
Also known as: Exercise mimetic · ERR pan-agonist · Exercise pill (preclinical)
SLU-PP-332 is a synthetic pan-agonist of the estrogen-related receptors (ERRα/β/γ), studied exclusively in mice for its ability to switch on an aerobic-exercise gene program — improving mitochondrial function and endurance without exercise. There is no human trial data as of the most recent research; everything known comes from murine studies using intraperitoneal dosing. This is the most investigational compound in this library — educational information only, not a basis for self-dosing.
What SLU-PP-332 is and how it works
SLU-PP-332 (named for its origin at Saint Louis University) is a small molecule designed to activate all three estrogen-related receptors (ERRα, ERRβ, ERRγ) at once. These receptors sit downstream of the same signaling pathway that endurance exercise naturally activates — the reason SLU-PP-332 earned the nickname “exercise mimetic” or “exercise pill” in early coverage.
In mouse studies, activating this pathway pharmacologically produced improvements in mitochondrial density, endurance capacity, and markers of cardiometabolic health — effectively some of the adaptations normally earned through aerobic training. That is a genuinely interesting mechanism, and it’s also exactly why the compound is generating research interest.
The honest caveat: this is preclinical research only. No human safety or efficacy trials exist. Anything resembling a “dose” below is a scaled description of what mice received in a lab, not a validated human protocol.
What the research protocols actually look like
Published murine studies used intraperitoneal (into the abdominal cavity) dosing, twice daily — a route and frequency that doesn’t translate directly to a subcutaneous human protocol:
- Weeks 1–2: 25 mg/kg, twice daily (mouse-equivalent)
- Weeks 3–8: 50 mg/kg, twice daily (mouse-equivalent)
| Vial | BAC water | Concentration | 1 unit (U-100) ≈ |
|---|---|---|---|
| 5 mg | 3 mL | 1.67 mg/mL | 16.7 mcg |
This table reflects the reconstitution math for the research vial format sold under this name, not a validated human dose. No reputable source describes a once-daily subcutaneous human protocol for SLU-PP-332 — the murine data is intraperitoneal and twice daily, and scaling animal mg/kg doses to humans isn’t straightforward or currently established.
Half-life & what it means for frequency
There is no published human half-life for SLU-PP-332 — it hasn’t been studied in people. What is known comes entirely from mouse pharmacokinetics, and even those aren’t established well enough to translate into a confident human dosing interval.
This is the key difference between SLU-PP-332 and everything else in this list: for compounds like retatrutide or AOD-9604, the open question is dosing strategy within a known human PK profile. For SLU-PP-332, the open question is whether a human PK profile exists at all yet.
What to track & common side effects
Because there is no human trial data, there is no established human side-effect profile either — good or bad. That absence of data is itself the most important fact about this compound, not a reason to assume safety.
If you’re tracking anything here, the honest framing is that you’re logging an n=1 self-experiment with a compound that has never been studied in a person — dose, timing, and any effect you notice, with appropriately low confidence in what any of it means.
How to track SLU-PP-332 in Stackeddd
If you are tracking SLU-PP-332, log dose and timing precisely — with no human trial data to compare against, your own log is the only record of what you actually took and when, which matters more here than with any established compound.
Model it yourself · free, no account
Reconstitution Calculator
Model it yourself: enter your vial size and BAC water and the Peptides tab returns concentration and units — the same math built into the Stackeddd app, regardless of how investigational the compound is.
Related compounds
Related reading: Peptide reconstitution math: how much BAC water to add
Frequently asked questions
What is SLU-PP-332 used for?
It’s a preclinical research compound that activates the ERRα/β/γ receptors, studied in mice for its ability to mimic aerobic-exercise adaptations — better mitochondrial function and endurance. No human trials have been conducted.
What is the half-life of SLU-PP-332?
Not established in humans — it has never been studied in people. Published data is limited to mouse pharmacokinetics from intraperitoneal dosing.
Is SLU-PP-332 an “exercise pill”?
That’s the informal nickname based on mouse studies showing it activates genes normally triggered by aerobic exercise. It is not an approved or clinically validated human exercise substitute.
Is SLU-PP-332 safe for humans?
Unknown — there is no human safety data. All available evidence is from murine studies, which is a meaningfully different (and much thinner) evidence base than compounds with completed human trials.
This is educational information, not medical advice. Doses and protocols above reflect published references and community practice — protocol decisions belong with your prescribing physician. Generic names used throughout. How this reference is built & how the AI is tested →
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