What Is Pinealon? Dosage, Half-Life & How to Track It
Also known as: Glu-Asp-Arg · EDR Peptide · Khavinson Bioregulator
Pinealon is a synthetic tripeptide — Glu-Asp-Arg — developed within Vladimir Khavinson’s bioregulator research program and studied mainly for neuroprotection. Protocols run 1.0–2.0 mg subcutaneously once daily, titrated upward across a 10–20 day cycle, repeated roughly every two to three months. Human dosing data is limited; this is preclinical-leaning research, and this page is educational only.
What Pinealon is and how it works
Pinealon is one of a family of short tripeptide “bioregulators” developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology — each one built around a specific three-amino-acid sequence and studied for tissue-targeted effects. Pinealon’s sequence, Glu-Asp-Arg, is associated in preclinical work with neuroprotection: protecting neurons from oxidative stress, and modulating gene expression involved in brain-cell function.
The research base here is real but narrow — mostly animal and cell-culture studies out of the same Russian research program, with far less independent replication or large human trial data than an approved drug would have. Treat it as an early-stage research peptide with a specific, plausible mechanism rather than an established cognitive treatment.
Typical dosing & reconstitution
Pinealon is reconstituted with bacteriostatic water — a 20 mg vial dissolved in 3 mL gives roughly 6.67 mg/mL, where one insulin-syringe unit carries about 66.7 mcg.
| Days | Daily dose | Units (U-100) ≈ |
|---|---|---|
| Days 1–5 | 1.0 mg | 15 units (0.15 mL) |
| Days 6–14 | 1.5 mg | 22.5 units (0.225 mL) |
| Days 15–20 | 2.0 mg | 30 units (0.30 mL) |
Standard cycles run 10–20 days, occasionally extended to 28, with repeat cycles spaced two to three months apart rather than continuous daily use. The reconstitution calculator converts any vial-and-water combination into exact units.
Half-life & why it’s cycled
No formal human half-life has been published for Pinealon. As a three-amino-acid peptide it’s expected to be broken down by circulating peptidases quickly — likely on the order of minutes — the same clearance pattern seen across this whole family of short bioregulator peptides.
That fast clearance is why the protocol is daily during the cycle rather than infrequent — there’s no depot to draw from — while the multi-month gap between cycles reflects how the underlying research was structured, not a known safety limit on continuous use.
What to track & considerations
Reported tolerability is generally favorable, with injection-site reaction being the main practical complaint. Because independent human safety data is limited, starting at the lower end of the range and paying attention to how you feel matters more here than with a well-studied compound.
Worth tracking: which day of the 10–20 day cycle you’re on, the dose that day, and whatever cognitive or wellbeing marker motivated the cycle in the first place — useful both in the moment and for deciding whether a repeat cycle is worth it.
How to track Pinealon in Stackeddd
Log each dose against the cycle day so you always know where you are in a 10–20 day run, and when the next cycle is actually due (two to three months out, not “whenever”). Reconstitution math is the same every cycle — set it up once and reuse it.
Model it yourself · free, no account
Reconstitution Calculator
Model it yourself: enter your vial size and BAC water and the Peptides tab returns concentration and exact syringe units for any dose in the cycle — the same math built into the Stackeddd app.
Related compounds
Related reading: Peptide reconstitution math: how much BAC water to add
Frequently asked questions
What is Pinealon used for?
Pinealon is a Khavinson tripeptide bioregulator studied preclinically for neuroprotection — protecting neurons from oxidative stress and supporting cognitive-relevant gene expression. Human trial data is limited.
What is the half-life of Pinealon?
No formal human half-life is published. As a tripeptide it’s expected to clear quickly (likely minutes) via normal peptidase breakdown, which is why it’s dosed daily during a cycle rather than infrequently.
How long is a Pinealon cycle?
Typically 10–20 days of once-daily subcutaneous dosing, occasionally extended to 28 days, with repeat cycles spaced roughly two to three months apart.
How do you reconstitute Pinealon?
Add 3 mL of bacteriostatic water to a 20 mg vial for about 6.67 mg/mL — a 1.5 mg dose is then roughly 22.5 units on a U-100 insulin syringe.
This is educational information, not medical advice. Doses and protocols above reflect published references and community practice — protocol decisions belong with your prescribing physician. Generic names used throughout. How this reference is built & how the AI is tested →
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