What Is Mazdutide? Dosage, Half-Life & How to Track It
Also known as: IBI362 · GLP-1/glucagon dual agonist
Mazdutide (development code IBI362) is a dual GLP-1/glucagon receptor agonist — the same two-pathway idea as survodutide, developed by Innovent Biologics and furthest along in China, where it has cleared regulatory approval. Trials show 6–14% weight loss over 24–48 weeks with mostly mild GI side effects. Its roughly week-long half-life supports once-weekly dosing, titrated from 2.5 mg up toward 10 mg. Educational information only; approval status varies by country.
What mazdutide is and how it works
Mazdutide activates two receptors — GLP-1 and glucagon — skipping GIP entirely, which puts it in the same mechanistic family as survodutide rather than tirzepatide. The glucagon component adds an energy-expenditure effect (the liver burning more fat for fuel) on top of the appetite suppression GLP-1 provides alone.
It has moved furthest in China, where Innovent Biologics has run it through Phase 3 trials for both weight management and type 2 diabetes, with regulatory approval there. In the US and elsewhere it remains investigational — worth knowing before assuming it has the same regulatory status as semaglutide or tirzepatide.
Reported trial weight loss (roughly 6–14% over 24–48 weeks) sits between single-agonist GLP-1 drugs and the higher numbers seen with triple agonists like retatrutide — consistent with adding one extra pathway rather than two.
Typical dosing & reconstitution
Titration follows the standard incretin pattern — slow steps, four weeks apart, to manage GI tolerability:
- Weeks 1–4: 2.5 mg
- Weeks 5–8: 5 mg
- Weeks 9–12: 7.5 mg
- Weeks 13+: 10 mg (higher-dose protocols)
| Vial | BAC water | Concentration | 1 unit (U-100) ≈ |
|---|---|---|---|
| 5 mg | 3 mL | 1.67 mg/mL | 16.7 mcg |
| 10 mg | 3 mL | 3.33 mg/mL | 33.3 mcg |
At 1.67 mg/mL, a 5 mg maintenance dose runs 300 units — three full 1 mL syringes — which is why higher-concentration mixes (a 10 mg vial in 2 mL, for example) are common once someone is past the early low-dose weeks. The calculator handles the trade-off for any vial you have.
Half-life & what it means for frequency
Mazdutide’s half-life runs in the same range as tirzepatide and retatrutide — roughly a week — which is what makes once-weekly dosing work and, again, means blood levels build gradually rather than resetting between shots.
The four-week hold at each titration step exists for the same reason it does with every drug in this half-life range: it takes several half-lives to reach steady state, so judging a dose after only a week or two is judging it before it has fully kicked in.
What to track & common side effects
Side effects are predominantly GI — nausea, diarrhea, and related symptoms — and trial data describes them as mostly mild, in the same range as other agents in this class.
The tracking priorities are unchanged from any GLP-class compound: weekly dose and titration step so escalation decisions are deliberate, and weight/waist as a trend rather than any single day’s number, alongside protein intake to protect lean mass through the loss.
How to track Mazdutide in Stackeddd
Log the weekly dose and titration rung so each step-up is a decision, not a guess, and trend weight and waist instead of chasing single readings. Keep protein in view — the same lean-mass math applies to mazdutide as to any GLP-class agent.
Model it yourself · free, no account
Blood-Level Simulator
Model it yourself: pick mazdutide, set your weekly dose, and watch levels build to steady state across the titration — the same pharmacokinetic engine that runs inside the app.
Related compounds
Related reading: Semaglutide vs Tirzepatide: half-life, cadence, and what to track · Peptide reconstitution math: how much BAC water to add
Frequently asked questions
What is mazdutide used for?
It’s a dual GLP-1/glucagon receptor agonist (development code IBI362) studied for weight management and type 2 diabetes, approved in China and investigational elsewhere. Trials show 6–14% weight loss over 24–48 weeks.
What is the half-life of mazdutide?
Roughly a week, in the same range as tirzepatide, which is what supports once-weekly dosing and means levels build gradually over the first several weeks at any dose.
How is mazdutide dosed?
Titration typically steps every 4 weeks — 2.5 mg, then 5, 7.5, and up to 10 mg on higher-dose protocols — once weekly, subcutaneous.
How is mazdutide different from survodutide?
Both are dual GLP-1/glucagon agonists with similar mechanisms; they differ mainly by developer (Innovent vs. Boehringer Ingelheim/Zealand) and regulatory progress — mazdutide is furthest along in China, survodutide in Western trials.
This is educational information, not medical advice. Doses and protocols above reflect published references and community practice — protocol decisions belong with your prescribing physician. Generic names used throughout. How this reference is built & how the AI is tested →
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