What Is Adamax? Dosage, Half-Life & How to Track It
Also known as: N-Acetyl Semax Amidate (Adamantane-Modified) · Adamantylated Semax
Adamax is an adamantane-modified version of Semax — the ACTH(4–10)-derived nootropic peptide — engineered for better stability and blood-brain-barrier penetration than the standard form. Protocols titrate from 300 mcg up to 1,000 mcg subcutaneously once daily over eight weeks. No formal human half-life is published; this page is educational information only.
What Adamax is and how it works
Adamax starts from Semax, itself a synthetic heptapeptide derived from a fragment of ACTH (adrenocorticotropic hormone) and studied for nootropic and neuroprotective effects. Standard Semax has a well-known weakness: it’s broken down quickly by peptidases, which is why it’s traditionally dosed intranasally, often multiple times a day, to keep exposure up.
Adamax addresses that by attaching an adamantane group to the Semax structure — a bulky, stable chemical addition that both improves resistance to enzymatic breakdown and appears to improve penetration across the blood-brain barrier. In preclinical comparisons, that combination is reported to make Adamax more potent than standard Semax at an equivalent dose.
As with Semax itself, the human evidence base is limited — most of what’s published is animal and mechanistic research into the ACTH(4–10) peptide family, not large controlled human trials of Adamax specifically.
Typical dosing & reconstitution
Adamax is reconstituted with bacteriostatic water — a 10 mg vial in 3 mL gives roughly 3.33 mg/mL, where one insulin-syringe unit is about 33.3 mcg.
| Weeks | Daily dose | Units (U-100) ≈ |
|---|---|---|
| Weeks 1–2 | 300 mcg | 9 units (0.09 mL) |
| Weeks 3–4 | 500 mcg | 15 units (0.15 mL) |
| Weeks 5–6 | 750 mcg | 23 units (0.23 mL) |
| Weeks 7–8 | 1,000 mcg | 30 units (0.30 mL) |
This dilution keeps the starting dose readable on a standard insulin syringe; a 30- or 50-unit syringe makes the smallest doses (9 units) even easier to measure precisely.
Half-life & what the adamantane modification changes
No formal human half-life has been published for Adamax specifically. What is documented is the reason it was built this way: unmodified Semax has a short functional window because normal peptidases degrade it quickly, and that’s the exact problem the adamantane modification is designed to solve.
The practical result is a compound that’s reported to hold up better once injected than plain Semax — enough to make once-daily subcutaneous dosing a reasonable schedule, versus the multiple-times-daily intranasal dosing standard Semax protocols often use.
What to track & side effects
Adamax is generally reported as well tolerated, consistent with the broader Semax/ACTH(4–10) peptide family’s track record; the main practical complaint is injection-site irritation. Formal human side-effect data specific to Adamax, though, doesn’t exist — reported tolerability is anecdotal.
What’s worth tracking is the titration week (so you know your current dose without recalculating) and whatever cognitive or mood marker prompted you to try it — journaled consistently is far more useful here than a memory of “I think it helped.”
How to track Adamax in Stackeddd
Log each dose against the titration week so the app tells you your current dose instead of you doing mental math from a table. Get the reconstitution locked in once — vial, water, concentration — and every week’s units are already there.
Model it yourself · free, no account
Reconstitution Calculator
Model it yourself: enter your vial size and BAC water and the Peptides tab returns concentration and exact syringe units for any dose in the titration — the same math built into the Stackeddd app.
Related compounds
Related reading: Peptide reconstitution math: how much BAC water to add
Frequently asked questions
What is Adamax used for?
Adamax is a modified Semax analog studied for nootropic and neuroprotective effects, via the ACTH(4–10) peptide pathway. It’s positioned as a more stable, more potent version of standard Semax rather than a distinct mechanism.
What is the half-life of Adamax?
No formal human half-life is published. Its adamantane modification is specifically designed to resist the fast peptidase breakdown that limits standard Semax, which is why once-daily subcutaneous dosing is used instead of multiple daily doses.
How is Adamax different from Semax?
Adamax is Semax with an added adamantane group, which improves stability and blood-brain-barrier penetration and is reported to increase potency versus the unmodified peptide.
How do you reconstitute Adamax?
Add 3 mL of bacteriostatic water to a 10 mg vial for roughly 3.33 mg/mL — a 500 mcg dose is then about 15 units on a U-100 insulin syringe.
This is educational information, not medical advice. Doses and protocols above reflect published references and community practice — protocol decisions belong with your prescribing physician. Generic names used throughout. How this reference is built & how the AI is tested →
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